Concordant acute myeloblastic leukemia in monozygotic twins with germline and shared somatic mutations in the gene for CCAAT-enhancer-binding protein a with 13 years difference at onset
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منابع مشابه
Concordant acute myeloblastic leukemia in monozygotic twins with germline and shared somatic mutations in the gene for CCAAT-enhancer-binding protein α with 13 years difference at onset.
Since the first report, very few monozygotic pairs of twins with concordant leukemia have been described. The interval between the onset of overt disease in each of the twins usually varies from some months to some years. Genetic changes in childhood acute leukemia are highly variable and patient specific (clone-specific genomic breakpoints and somatic mutations). Therefore, the finding of a sh...
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